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Amphetamine is known to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit different P450 isozymes and also other enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes show insignificant inhibition of CYP2D6 by amphetamine and small inhibition of CYP1A2, 2D6, and 3A4 by o